Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Educating young people about how to interact with patients at the end of their lives is challenging. A qualitative study based on Husserl’s phenomenological approach was performed to describe the learning experience of secondary education students after watching, analysing, and reflecting on two videoclips featuring Cameron Duncan, a young man suffering from terminal cancer. Students from three vocational centres providing training in ancillary nursing, pharmacy, and dependent care in the Community of Madrid visited the Palliative Care Hospital. A total of (...) 110 students, with a median age of nineteen years, participated in the study. The students’ learning experience through the videoclips reveals the essential aspects required in palliative care, since the character suffers in every dimension of his being: physically as well as psychologically, socially, and spiritually. Therefore, this requires healthcare professionals to understand their experience, putting themselves in their place, to provide affectionate care and to display communication skills leading to a quality helping relationship. Four comprehensive educational categories were identified in the study. The students learned the importance of: 1) providing comprehensive and affectionate care to patients, 2) the need for communication skills in caring for patients, 3) being aware of the end of life and time left, 4) valuing life and fighting for what one wishes to attain. A visit to a PC hospital and the viewing of videoclips and reflection upon these, represents a useful strategy for secondary education healthcare students. The study indicates that videoclips are an innovative method for becoming aware of the various issues pertaining to palliative care. (shrink)

A bibliometric index is proposed that accounts for the differential contribution authors make to a joint paper published, the valuation of the number of publications, the quality of the journals in which the authors are published and which cite them, as well as the timeliness of the paper. This approach means the index can be used in selection processes for positions of employment or the award of research projects, as it abides by the premise of considering scientific merit based on (...) the quality and quantity of publications. The term weighted citability index is used to refer to a mathematical process that uses filters proportionally both to the degree of involvement in the joint research and to the values of number, quality, and timeliness of the research papers. (shrink)

BackgroundBased on an actual case in which a psychiatrist was called in to assess a patient’s capacity to refuse treatment, the aim of this study is to discuss how to manage this ethical and clinical issue and the dilemmas faced by the medical team.Case presentation: The case involved a 45-year-old female patient diagnosed with breast cancer who refused treatment. Since the mastology team had doubts about the patient’s mental state and given that she refused to consent to surgery, a forensic (...) psychiatric consult was requested.ConclusionThe forensic psychiatry team concluded that the patient’s decision-making capacity was preserved. The team suggested some actions to help the specialists deal with the ethical conflict. A reflection is proposed about the role of psychiatrists when an ethical dilemma involving decision-making capacity emerges in clinical situations, elucidating their work not only as physicians who determine diagnoses and conducts, but also as agents of transformation in the doctor–patient re... (shrink)

Natural deduction systems for classical, intuitionistic and modal logics were deeply investigated by Prawitz [D. Prawitz, Natural Deduction: A Proof-theoretical Study, in: Stockholm Studies in Philosophy, vol. 3, Almqvist and Wiksell, Stockholm, 1965. Reprinted at: Dover Publications, Dover Books on Mathematics, 2006] from a proof-theoretical perspective. Prawitz proved weak normalization for classical logic only for a language without logical or, there exists and with a restricted application of reduction ad absurdum. Reduction steps related to logical or, there exists and classical (...) negation bring about many problems solved only rather recently. For classical S5 modal logic, Prawitz defined a normalizable system, but for a language without logical or, there exists, ◊ and, for a propositional language without ◊, Medeiros [M.da P.N. Medeiros, A new S4 classical modal logic in natural deduction, Journal of Symbolic Logic 71 799–809] presented a normalizable system for classical S4. We can mention many cut-free Gentzen systems for S4, S5 and K45/K45D, some normalizable natural deduction systems for intuitionistic modal logics and one more for full classical S4, but not for full classical S5. Here our focus is on the definition of a classical and normalizable natural deduction system for S5, taking not only □ and ◊ as primitive symbols, but also all connectives and quantifiers, including classical negation, disjunction and the existential quantifier. The normalization procedure is based on the strategy proposed by Massi [C.D.B. Massi, Provas de normalizaçaõ para a lógica clássica, Ph.D. Thesis, Departamento de Filosofia, UNICAMP, Campinas, 1990] and Pereira and Massi [L.C. Pereira, C.D.B. Massi, Normalização para a lógica clássica, in: O que nos faz pensar, Cadernos de Filosofia da PUC-RJ, vol. 2, 1990, pp. 49–53] for first-order classical logic to cope with the combined use of classical negation, disjunction and the existential quantifier. Here we extend such results to deal with □ and ◊ too. The elimination rule for ◊ uses the notions of connection and of essentially modal formulas already proposed by Prawitz for the introduction of □. Beyond weak normalization, we also prove the subformula property for full S5. (shrink)

INDICE -/- Note biografiche Introduzione, di Riccardo Faucci -/- Parte I - Da Verri a Toniolo 1. Jeremy Bentham: Contemporary Interpretations, di M.D.A. Freeman 2. Su Helvétius, Beccaria e Bentham, di Letizia Gianformaggio 3. L'etica utilitaristica di Pietro Veti, di Vincenzo Polignano 4. ll liberismo interventista di Vincenzo Emanuele Sergio, di Anna Li Donni 5. Il concetto di " felicità pubblica, nella << Genesi del diritto penale » di Romagnosi, e il rapporto Romagnosi-Bentham, di Robertino Ghiringhelli 6. « La più (...) grande felicità per il maggior numero » all'Accademia dei Georgofili ( 18)0-1850), di Gabriella Gioli 7. Una nota su Manzoni critico dell'utilitarismo, di Maurizio Mori 8. Sul concetto di utile in Francesco Ferrara e in Maffeo Pantaleoni, di Daniela Parisi Acquaviva 9. Sul pensiero sociale cristiano di fronte all'edonismo, di Luciano Avagliano 10. Giuseppe Toniolo e il recupero cattolico dell'utile e del valore, di Anna Camaiti -/- Parte II Aspetti di storia del pensiero economico nell’età classica -/- 1. La filosofia economica di Thomas Hobbes, di Marco Bertozzi 2. Ordinamento del sapere, modelli metodologici ed economia politica in Adam Smith, di Sergio Cremaschi 3. Elementi classici nel pensiero di Adam Smith: giurisprudenza romana e morale stoica, di Gloria Vivenza 4. Il “lusso” negli economisti italiani del Settecento, di Cosimo Perrotta 5. Prezzi naturali, prezzi di mercato e legge degli sbocchi nel dibattito fra Malthus e Ricardo, di Lilia Costabile 6. Marx e la moneta, di Roberto Petrini -/- . (shrink)

José M. Arana (a), Fernando Gordillo (b), Lilia Mestas (c) y Miguel Ángel Pérez (b) (a) Dept. de Psicología Básica, … Read More →.

Fernando Gordillo (a), Lilia Mestas (b), Miguel Ángel Pérez (a), José Héctor Lozano (a), Rafael Manuel López (a), José M. … Read More →.

Fernando Gordillo, Lilia Mestas, José M. Arana, Juan José G. Meilán, Miguel A. Pérez … Read More →.

In lieu of an abstract, here is a brief excerpt of the content:The Senatus Consultum de Cn. Pisone PatreD. S. PotterTranslated by Cynthia DamonEditorial Conventions( ) expansion of abbreviation[ ] restoration of letters written but now missing{ } deletion of letters written by mistake[ ] correction of letters considered wrongly inscribed necessary supplements > in translation, material supplied for clarity1 A(nte) d(iem) IIII eid(us) Dec(embres) in Palatio in porticu, quae est ad Apollinis. Scribendo2 adfuerunt M(arcus) Valerius M(arci) f(ilius) Lem(onia tribu) (...) Messallinus, G(aius) Ateius L(uci) f(ilius) Ani(ensi tribu) Capito, Sex(tus) Pomp(eius)3 Sex(ti) f(ilius) Arn(ensi tribu), M(arcus) Pompeius M(arci) f(ilius) Teret(ina tribu) Priscus, G(aius) Arrenus G(ai) f(ilius) Gal(eria tribu) Gallus, L(ucius) Nonius L(uci) f(ilius)4 Pom(ptina tribu) Asprenas q(uaestor), M(arcus) Vinicius P(ubli) f(ilius) Pob(lilia tribu) q(uaestor). vacat Quod Ti(berius) Caesar divi Aug(usti) f(ilius) Aug(ustus)5 pontifex maxumus, tribunicia potestate XXII, co(n)s(ul) III, designatus IIII ad sena– tum rettulit qualis causa Cn. Pisonis patris visa esset et an merito sibi mor– tem conscisse videretur et qualis causa M. Pisonis visa esset, cui relationi ad– iecisset, uti precum suarum pro adulescente memor is ordo esset, qualis cau– sa Plancinae visa esset, pro qua persona, quid petisset et quas propter causas,10 exposuisset antea, et quid de Visellio Karo et de Sempronio Basso, comitibus Cn. Pisonis patris, iudicaret senatus, d(e) i(is) r(ebus) i(ta) c(ensuerunt). vacat senatum populumq(ue) Romanum ante omnia dis immortalibus gratias agere, [End Page 14]1 December 10, on the Palatine in the portico adjacent to the Temple of Apollo. Present at the writing were M. Valerius M.f. Messallinus from the voting tribe Lemonia, C. Ateius L. f. Capito from the voting tribe Aniensis, Sex. Pompeius Sex. f. from the voting tribe Arnensis, M. Pompeius M. f. Priscus from the voting tribe Teretina, C. Arrenus C. f. Gallus from the voting tribe Galeria; L. Nonius L. f. Asprenas from the voting tribe Pomptina, quaestor, M. Vinicius P. f. from the voting tribe Poblilia, quaestor.WHEREAS Ti. Caesar Augustus, son of the deified Augustus, 5 pontifex maxumus,> in the twenty–second year of his tribunician power, having been consul three times, consul–designate for the fourth time, referred to the Senate for decision:how the case of the elder Cn. Piso had seemed and whether he seemed to have taken his life with due cause, andhow the case of M. Piso had seemed (to which item he had added that the senators be mindful of his entreaties on behalf of the young man); how the case of Plancina had seemed (for which person 10 he had previously explained what he sought and for what reasons), andwhat the Senate's judgment was concerning Visellius Karus and Sempronius Bassus, members of the elder Cn. Piso's staff,Concerning These Matters they Decreed as Follows:THAT the Senate and Roman people, before all else, expressed gratitude to the immortal gods because they did [End Page 15]quod nefaris consilis Cn. Pisonis patris tranquillitatem praesentis status r(ei) p(ublicae), quo melior optari non pote [e]t quo beneficio principis nostri frui contigit,15 turbar[i] passi non sunt, deinde Ti. Caesari Augusto principi suo quod earum rerum omnium, quae ad explorandam veritatem necessariae fuerunt, co– piam senatui fecerit, cuius aequitatem et patientiam hoc quoq(ue) nomine admirari senatum, quod, cum manufestissuma sint Cn. Pisonis patris scelera et ipse de se supplicium sumpsisset, nihilominus causam eius cognosci volue–20 rit filiosque eius arcessitos hortatus sit, ut patris sui causam defenderent, ita ut eum quoq(ue), qui ordinis senatori nondum esset, ob eam rem introduci in senatum vellet et copiam utriq(ue) dicendi pro patre et pro matre ipsorum et pro M. Pisone faceret. Itaque cum per aliquot dies acta causa sit ab accusatoribus Cn. Pisonis patris et ab ipso Cn. Pisone patre, recitatae epistulae, recitata exemplaria codicillorum, quos25 Germanicus Caesar Cn. Pisoni patri scripsisset, producti testes cuiusq(ue) ordinis sint, [End Page 16]not allow the tranquility of the present state of the republic... (shrink)

Sensible people advise one not to expend one's strength on polemics. And sensible people are right, of course. But look at the history of social thought: there is no peace beneath the olives, and without the flames of social thought, even the pure light of science begins to flicker.

The Journal of Mind and Behavior, Winter 2003, Volume 24, Number 1, Pages 91–118, ISSN 0271–0137 This paper focuses on a logical systems flow-down of a set of consciousness requirements, which together with biological quantification of human brain anatomy sets limits on the neurological network in the cerebrum in order to produce the mind. It employs data to validate inferences, or when data do not exist, proposes methods for acquiring valid evidence. Many of these systems requirements will be imposed after (...) some fundamental assumptions are made. These assumptions are not new to theories on consciousness. However, their application as fundamentals may actually represent a new approach. Concurrent with these fundamentals, explicit periods of awareness while conscious are employed. Justification for their use is found in a theoretical process described as cerebral fusion. Additionally, storage of memory elements is postulated within local glia sites, proximal to synaptic nodes, and conductive transport through the astrocytes responsible for recall of data. The model permits variations in neural–glial interface physics and allows forecasts of mind/brain dysfunctions to be inferred. One key result from the model is hypothesized and expanded upon, and may have impact in certain types of dementia, such as Alzheimer’s disease. (shrink)

Genetic and environmental factors leading to Alzheimer's disease (AD) converge in a pathogenic pathway that leads to the accumulation of mis‐folded amyloid peptide (Aβ) in the brain. Removal of Aβ from the brain has thus been the focus of academic and industrial research in the last decade. The concept of immunization therapy could be proven in animal models mimicking amyloid pathology but a multicenter clinical trial in which AD patients were vaccinated with aggregated Aβ has resulted in somewhat unanticipated and (...) partially conflicting results. The occurrence of meningoencephalitis in 6% of vaccinated individuals forced the discontinuation of the clinical study, preventing the generation of sufficient data for an unequivocal statement about the effectiveness of such a therapy approach. This study, however, clearly showed that vaccination induced the production of antibodies against Aβ in some immunized patients. Moreover, circulating anti‐Aβ antibodies are found in healthy humans suggesting a protective role of such physiological antibodies. Nonetheless, the physiological role of the immune system in preventing AD is not fully understood. This article summarizes crucial animal and clinical data underscoring the potential of the immune system for AD treatment. BioEssays 29:927–932, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Objectives: The introduction of the living donation in organ transplantation introduces important new psychological conflicts and ethical questions in the transplantation process. Operation related risks, as well as dependencies in the family structure, generate considerable pressure on potential donors. The aim of the study was to reconstruct the determinants of willingness to donate before transplantation.Methods: Evaluation of 20 taped and transcribed interviews oriented to current approaches in qualitative interview research. The approach used is based on grounded theory, qualitative content analysis, (...) and the concept of the ideal type.Results: Before surgery, “openly motivated” donors push for an operation, leaving no room for ambivalence in the evaluation process. They idealise the relationship with the recipient, and link their donation with the individual—partly in subconscious expectations and wishes. In contrast, “openly ambivalent” donors formulate their anxieties and express arguments against donation.Conclusions: Statements that claim ambivalence towards donation or utterance of arguments against donation indicate earlier coercion. Before transplantation, potential donors should have the opportunity to discuss their emotional situation to help their decision making process. (shrink)